Saturday, September 24, 2011

Q: What is HTK solution?

Answer: HTK stands for Histidine-tryptophan-ketoglutarate. It is a preservation solution used for organ transplantation, intended for perfusion and flushing of donor liver, kidney, heart, lung and pancreas prior to removal from the donor and for preserving these organs during hypothermic storage and transport to the recipient.

The composition of HTK is similar to that of extracellular fluid. It also contains Histidine which does intensive buffering of the extracellular space, so as to prolong the period during which the organs will tolerate interruption of oxygenated blood. It also contains Mannitol and its Osmolarity is 310 mOsm/L.


Reference: click to get article

Transplantation: HTK solution: should it replace UW solution for kidney preservation? , Nature Reviews Nephrology 5, 429 (August 2009)